Wissenschaftliche Veröffentlichungen

2022

Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó , Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. Luning Prak, David Allman, Michela Locci, Norbert Pardi:

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [Correction]

Immunity 55(6): 1136–1138 (2022)

Correction to: Immunity 54(12): 2877-2892.e1-e7 (2021)

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Katalin Karikó:

Developing mRNA for therapy [Abstract - The Keio Medical Science Prize 2021 Commemorative Lecture]

The Keio Journal of Medicine 71(1): 31 (2022)

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Hiromi Muramatsu, Kieu Lam, Csaba Bajusz, Dorottya Laczkó, Katalin Karikó, Petra Schreiner, Alan Martin, Peter Lutwyche, James Heyes, Norbert Pardi:

Lyophilization provides long-term stability for a lipid nanoparticle-formulated, nucleoside-modified mRNA vaccine [Original Article]

Molecular Therapy 30(5): 1941-1951 (2022)

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Ronit Nir, Thomas Philipp Hoernes, Hiromi Muramatsu, Klaus Faserl, Katalin Kariko, Matthias David Erlacher, Aldema Sas-Chen, Schraga Schwartz:

A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA [Open Access Article]

Nucleic Acids Research 50(9): 4900–4916 (2022)

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Irena Vlatkovic, János Ludwig, Gábor Boros, Gábor Tamás Szabó, Julia Reichert, Maximilian Buff, Markus Baiersdörfer, Jonas Reinholz, Azita Josefine Mahiny, Ugur ̧Sahin, Katalin Karikó:

Ribozyme assays to quantify the capping efficiency of in vitro-transcribed mRNA [Open Access Article]

Pharmaceutics 14(2): N^o328 (2022)

2021

Jessica B. Foster, Crystal Griffin, Jo Lynne Rokita, Allison Stern, Cameron Brimley, Komal Rathi, Maria V. Lane, Samantha N. Buongervino, Tiffany Smith, Peter J. Madsen, Daniel Martinez, Robert J. Wechsler-Reya, Katalin Karikó, Phillip B. Storm, David M. Barrett, Adam C. Resnick, John M. Maris, Kristopher R. Bosse:

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors [New Results]

bioRxiv - Cancer Biology Pub Date: 2021-08-26, DOI

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Katalin Karikó, Kathryn Whitehead, Roy van der Meel:

What does the success of mRNA vaccines tell us about the future of biological therapeutics? [Voices]

Cell Systems 12(8): 757–758 (2021)

[Elsevier Public Health Emergency Collection / Public Health Emergency COVID-19 Initiative]

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Mohamad-Gabriel Alameh, István Tombácz, Emily Bettini, Katlyn Lederer, Chutamath Sittplangkoon, Joel R. Wilmore, Brian T. Gaudette, Ousamah Y. Soliman, Matthew Pine, Philip Hicks, Tomaz B. Manzoni, James J. Knox, John L. Johnson, Dorottya Laczkó, Hiromi Muramatsu, Benjamin Davis, Wenzhao Meng, Aaron M. Rosenfeld, Shirin Strohmeier, Paulo J.C. Lin, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Alain Jacquet, Florian Krammer, Paul Bates, Michael P. Cancro, Drew Weissman, Eline T. Luning Prak, David Allman, Michela Locci, Norbert Pardi:

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses [Article]

Immunity 54(12): 2877-2892.e7 (2021)

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Ugur Sahin, Alexander Muik, Isabel Vogler, Evelyna Derhovanessian, Lena M. Kranz, Mathias Vormehr, Jasmin Quandt, Nicole Bidmon, Alexander Ulges, Alina Baum, Kristen E. Pascal, Daniel Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Peter Koch, Rolf Hilker, Dirk Becker, Ann Kathrin Eller, Jan Grützner, Manuel Tonigold, Carsten Boesler, Corinna Rosenbaum, Ludwig Heesen, Marie Cristine Kühnle, Asaf Poran, Jesse Z. Dong, Ulrich Luxemburger, Alexandra Kemmer-Brück, David Langer, Martin Bexon, Stefanie Bolte, Tania Palanche, Armin Schultz, Sybille Baumann, Azita J. Mahiny, Gábor Boros, Jonas Reinholz, Gábor T. Szabó, Katalin Karikó, Pei Yong Shi, Camila Fontes-Garfias, John L. Perez, Mark Cutler, David Cooper, Christos A. Kyratsous, Philip R. Dormitzer, Kathrin U. Jansen, Özlem Türeci:

BNT162b2 vaccine induces neutralizing antibodies and poly-specific T cells in humans [Article]

Nature 595: 572–577 (2021)

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Dániel Szőke, Gábor Kovács, Éva Kemecsei, László Bálint, Kitti Szoták-Ajtay, Petra Aradi, Andrea Styevkóné Dinnyés, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Katalin Karikó, Raghu P. Kataru, Michael J. Hope, Drew Weissman, Babak J. Mehrara, Norbert Pardi, Zoltán Jakus:

Nucleoside-modified VEGFC mRNA induces organ-specific lymphatic growth and reverses experimental lymphedema [Article]

Nature Communications 12: N^o3460 (2021)

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Katalin Karikó:

Modified uridines are the key to a successful message [Journal Club]

Nature Reviews Immunology 21: 619 (2021)

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Christina Krienke, Laura Kolb, Elif Diken, Michael Streuber, Sarah Kirchhoff, Thomas Bukur, Özlem Akilli-Öztürk, Lena M. Kranz, Hendrik Berger, Jutta Petschenka, Mustafa Diken, Sebastian Kreiter, Nir Yogev, Ari Waisman, Katalin Karikó, Özlem Türeci, Ugur Sahin:

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis [Research article]

Science 371(6525): 145-153 (2021)

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Christian Hotz, Timothy R. Wagenaar, Friederike Gieseke, Dinesh S. Bangari, Michelle Callahan, Hui Cao, Jan Diekmann, Mustafa Diken, Christian Grunwitz, Andy Hebert, Karl Hsu, Marie Bernardo, Katalin Karikó, Sebastian Kreiter, Andreas N. Kuhn, Mikhail Levit, Natalia Malkova, Serena Masciari, Jack Pollard, Hui Qu, Sue Ryan, Abderaouf Selmi, Julia Schlereth, Kuldeep Singh, Fangxian Sun, Bodo Tillmann, Tatiana Tolstykh, William Weber, Lena Wicke, Sonja Witzel, Qunyan Yu, Yu-An Zhang, Gang Zheng, Joanne Lager, Gary J. Nabel, Ugur Sahin, Dmitri Wiederschain:

Local delivery of mRNA-encoded cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

Science Translational Medicine 13(610): eabc7804 (2021)

2020

Dorottya Laczkó, Michael J. Hogan, Sushila A. Toulmin, Philip Hicks, Katlyn Lederer, Brian T. Gaudette, Diana Castaño, Fatima Amanat, Hiromi Muramatsu, Thomas H. Oguin, Amrita Ojha, Lizhou Zhang, Zekun Mu, Robert Parks, Tomaz B. Manzoni, Brianne Roper, Shirin Strohmeier, István Tombácz, Leslee Arwood, Raffael Nachbagauer, Katalin Karikó, Jack Greenhouse, Laurent Pessaint, Maciel Porto, Tammy Putman-Taylor, Amanda Strasbaugh, Tracey-Ann Campbell, Paulo J.C. Lin, Ying K. Tam, Gregory D. Sempowski, Michael Farzan, Hyeryun Choe, Kevin O. Saunders, Barton F. Haynes, Hanne Andersen, Laurence C. Eisenlohr, Drew Weissman, Florian Krammer, Paul Bates, David Allman, Michela Locci, Norbert Pardi:

A single immunization with nucleoside-modified mRNA vaccines elicits strong cellular and humoral immune responses against SARS-CoV-2 in mice [Report]

Immunity 53(4): 724-732 (2020)

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Ugur Sahin, Alexander Muik, Evelyna Derhovanessian, Isabel Vogler, Lena M. Kranz, Mathias Vormehr, Alina Baum, Kristen Pascal, Jasmin Quandt, Daniel Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Rolf Hilker, Dirk Becker, Ann-Kathrin Eller, Jan Grützner, Carsten Boesler, Corinna Rosenbaum, Marie-Cristine Kühnle, Ulrich Luxemburger, Alexandra Kemmer-Brück, David Langer, Martin Bexon, Stefanie Bolte, Katalin Karikó, Tania Palanche, Boris Fischer, Armin Schultz, Pei-Yong Shi, Camila Fontes-Garfias, John L. Perez, Kena A. Swanson, Jakob Loschko, Ingrid L. Scully, Mark Cutler, Warren Kalina, Christos A. Kyratsous, David Cooper, Philip R. Dormitzer, Kathrin U. Jansen, Özlem Türeci:

COVID-19 vaccine BNT162b1 elicits human antibody and T_H1 T cell responses [Article]

Nature 586(7830): 594-599 (2020)

Publisher Correction: Nature 590(7844): E17 (2021)

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Concurrent human antibody and T_H1 type T-cell responses elicited by a COVID-19 RNA vaccine

Cold Spring Harbor Laboratory, BMJ, Yale University (2020)

medRxiv (Internet site distributing unpublished eprints about health sciences)

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Ugur Sahin, Alexander Muik, Isabel Vogler, Evelyna Derhovanessian, Lena M. Kranz, Mathias Vormehr, Jasmin Quandt, Nicole Bidmon, Alexander Ulges, Alina Baum, Pascal, Daniel Maurus, Sebastian Brachtendorf, Verena Lörks, Julian Sikorski, Peter Koch, Hilker, Dirk Becker, Ann-Kathrin Eller, Jan Grützner, Manuel Tonigold, Carsten Boesler, Corinna Rosenbaum, Ludwig Heesen, Marie-Cristine Kühnle, Asaf Poran, Jesse Z. Dong, Ulrich Luxemburger, Alexandra Kemmer-Brück, David Langer, Martin Bexon, Stefanie Bolte, Tania Palanche, Armin Schultz, Sybille Baumann, Azita J. Mahiny, Gábor Boros, Jonas Reinholz, Gábor T. Szabó, Katalin Karikó, Pei-Yong Shi, Camila Fontes-Garfias, John L. Perez, Mark Cutler, David Cooper, Christos A. Kyratsous, Philip R. Dormitzer, Kathrin U. Jansen, Özlem Türeci:

BNT162b2 induces SARS-CoV-2-neutralising antibodies and T cells in humans

Cold Spring Harbor Laboratory, BMJ, Yale University (2020)

medRxiv (Internet site distributing unpublished eprints about health sciences)

2019

Jessica B. Foster, Namrata Choudhari, Jessica Perazzelli, Julie Storm, Ted J. Hofmann, Payal Jain, Phillip B. Storm, Norbert Pardi, Drew Weissman, Angela J. Waanders, Stephan A. Grupp, Katalin Karikó, Adam C. Resnick, David M. Barrett:

Purification of mRNA encoding chimeric antigen receptor is critical for generation of a robust T-cell response

Human Gene Therapy 30(2): 168-178 (2019)

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Katalin Karikó:

In vitro-transcribed mRNA therapeutics: out of the shadows and into the spotlight [Editorial]

Molecular Therapy 27(4): 691-692 (2019)

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Jessica B. Foster, David M. Barrett, Katalin Karikó:

The emerging role of in vitro-transcribed mRNA in adoptive T cell immunotherapy [Review]

Molecular Therapy 27(4): 747-756 (2019)

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Markus Baiersdörfer, Gábor Boros, Hiromi Muramatsu, Azita Mahiny, Irena Vlatkovic, Ugur Sahi, Katalin Karikó:

A facile method for the removal of dsRNA contaminant from in vitro-transcribed mRNA [Article]

Molecular Therapy: Nucleic Acids 15: 26-35 (2019)

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Norbert Pardi, Celia C. LaBranche, Guido Ferrari, Derek W. Cain, István Tombácz, Robert J. Parks, Hiromi Muramatsu, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Patricia Polacino, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Barton F. Haynes, David C. Montefiori, Shiu-Lok Hu, Drew Weissman:

Characterization of HIV-1 nucleoside-modified mRNA vaccines in rabbits and rhesus macaques [Article]

Molecular Therapy: Nucleic Acids 15: 36-47 (2019)

2018

Timothy R. Wagenaar, Christian Hotz, Friederike Gieseke, Hui Cao, Jan Diekmann, Mustafa Diken, Christian Grunwitz, Andy Hebert, Karl Hsu, Marie Jordan, Katalin Kariko, Sebastian Kreiter, Andreas N. Kuhn, Mikhail Levit, Natalia Malkova, Serena Masciari, Jack Pollard, Hui Qu, Abderaouf Selmi, Julia Schlereth, Fangxian Sun, Bodo Tillmann, Tatiana Tolstykh, Lena Wicke, Sonja Witzel, Qunyan Yu, Yu-An Zhang, Gang Zheng, Gary Nabel, Joanne Lager, Ugur Sahin, Dmitri Wiederschain:

Combinatorial treatment with intratumoral cytokine mRNAs results in high frequency of tumor rejection and development of anti-tumor immunity across a range of preclinical cancer models [Abstract]

Proceedings of the American Association for Cancer Research Annual Meeting; Chicago, IL; 14-18 April 2018.

Cancer Research 78(13 Suppl): N^o LB-130 (2018)

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Norbert Pardi, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M. Anthony Moody, Hans P. Verkerke, Arpita Myles, Elinor Willis, Celia C. LaBranche, David C. Montefiori, Jenna L. Lobby, Kevin O. Saunders, Hua‑Xin Liao, Bette T. Korber, Laura L. Sutherland, Richard M. Scearce, Peter T. Hraber, István Tombácz, Hiromi Muramatsu, Houping Ni, Daniel A. Balikov, Charles Li, Barbara L. Mui, Ying K. Tam, Florian Krammer, Katalin Karikó, Patricia Polacino, Laurence C. Eisenlohr, Thomas D. Madden, Michael J. Hope, Mark G. Lewis, Kelly K. Lee, Shiu‑Lok Hu, Scott E. Hensley, Michael P. Cancro, Barton F. Haynes, Drew Weissman:

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses [Article]

Journal of Experimental Medicine 215(6): 1571–1588 (2018)

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Shida Yousefi, Satish K. Sharma, Darko Stojkov, Nina Germic, Salome Aeschlimann, Moyar Q. Ge, Cameron H. Flayer, Erik D. Larson, Imre G. Redai, Suhong Zhang, Cynthia J. Koziol-White, Katalin Karikó, Hans-Uwe Simon, Angela Haczku:

Oxidative damage of SP‐D abolishes control of eosinophil extracellular DNA trap formation [Brief conclusive report]

Journal of Leukocyte Biology 104(1): 205-214 (2018)

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Norbert Pardi, Kaela Parkhouse, Ericka Kirkpatrick, Meagan McMahon, Seth J. Zost, Barbara L. Mui, Ying K. Tam, Katalin Karikó, Christopher J. Barbosa, Thomas D. Madden, Michael J. Hope, Florian Krammer, Scott E. Hensley, Drew Weissman:

Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies [Article]

Nature Communications 9: N^o3361 (2018)

2017

Norbert Pardi, Michael J. Hogan, Rebecca S. Pelc, Hiromi Muramatsu, Hanne Andersen, Christina R. DeMaso, Kimberly A. Dowd, Laura L. Sutherland, Richard M. Scearce, Robert Parks, Wendeline Wagner, Alex Granados, Jack Greenhouse, Michelle Walker, Elinor Willis, Jae-Sung Yu, Charles E. McGee, Gregory D. Sempowski, Barbara L. Mui, Ying K. Tam, Yan-Jang Huang, Dana Vanlandingham, Veronica M. Holmes, Harikrishnan Balachandran, Sujata Sahu, Michelle Lifton, Stephen Higgs, Scott E. Hensley, Thomas D. Madden, Michael J. Hope, Katalin Karikó, Sampa Santra, Barney S. Graham, Mark G. Lewis, Theodore C. Pierson, Barton F. Haynes & Drew Weissman:

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination [Letter]

Nature 543: 248-251 (2017)

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Norbert Pardi, Anthony J. Secreto, Xiaochuan Shan, Fotini Debonera, Joshua Glover, Yanjie Yi, Hiromi Muramatsu, Houping Ni, Barbara L. Mui, Ying K. Tam, Farida Shaheen, Ronald G. Collman, Katalin Karikó, Gwenn A. Danet-Desnoyers, Thomas D. Madden, Michael J. Hope, Drew Weissman:

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge [Article]

Nature Communications 8: N^o 14630 (2017)

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Christiane R Stadler, Hayat Bähr-Mahmud, Leyla Celik, Bernhard Hebich, Alexandra S Roth, René P Roth, Katalin Karikó, Özlem Türeci, Ugur Sahin:

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies [Brief communication]

Nature Medicine 23(7): 815-817 (2017). Corrected after print (online).

2016

Gábor Boros, Katalin Karikó, Hiromi Muramatsu, Edit Miko, Eszter Emri, Csaba Hegedűs, Gabriella Emri, Éva Remenyik:

Transfection of human keratinocytes with nucleoside-modified mRNA encoding CPD-photolyase to repair DNA damage

In: Rhoads R. (eds): Synthetic mRNA. Methods in Molecular Biology, vol. 1428. Humana Press, New York, NY, 2016, pp 219-228.

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Azita Josefine Mahiny, Katalin Karikó:

Measuring hematocrit in mice injected with in vitro-transcribed erythropoietin mRNA

In: Rhoads R. (eds): Synthetic mRNA. Methods in Molecular Biology, vol. 1428. Humana Press, New York, NY, 2016, pp 297-306.

2015

Norbert Pardi, Steven Tuyishime, Hiromi Muramatsu, Katalin Kariko, Barbara L. Mui, Ying K. Tam, Thomas D. Madden, Michael J. Hope, Drew Weissman:

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes [Article]

Journal of Controlled Release 217: 345–351 (2015)

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Drew Weissman, Katalin Karikó:

mRNA: Fulfilling the promise of gene therapy [Commentary]

Molecular Therapy 23(9): 1416-1417 (2015)

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Gábor Boros, Edit Miko, Hiromi Muramatsu, Drew Weissman, Eszter Emri, Gijsbertus T. J. van der Horst, Andrea Szegedi, Irén Horkay, Gabriella Emri ,Katalin Karikó, Éva Remenyik:

Identification of cyclobutane pyrimidine dimer-responsive genes using UVB-irradiated human keratinocytes transfected with in vitro-synthesized photolyase mRNA [Research Article]

PLoS ONE 10(6): e0131141 (2015)

2014

Norbert Pardi, Katalin Kariko, Michael Hogan, Hiromi Muramatsu, James A. Hoxie, Drew Weissman:

Generating an anti-HIV vaccine using nucleoside-modified mRNA encoding envelope [Abstract]

AIDS Research and Human Retroviruses 30(S1): A249 (2014)

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Ugur Sahin, Katalin Karikó, Özlem Türeci:

mRNA-based therapeutics - developing a new class of drugs [Review]

Nature Reviews Drug Discovery 13: 759-780 (2014)

2013

B.R. Anderson, K. Karikó, D. Weissman:

Nucleofection induces transient eIF2α phosphorylation by GCN2 and PERK [Original article]

Gene Therapy 20: 136–142 (2013)

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Gábor Boros, Edit Miko, Hiromi Muramatsu, Drew Weissman, Eszter Emri, Dávid Rózsa, Georgina Nagy, Attila Juhász, István Juhász, Gijsbertus van der Horst, Irén Horkay, Éva Remenyik, Katalin Karikó, Gabriella Emri:

Transfection of pseudouridine-modified mRNA encoding CPD-photolyase leads to repair of DNA damage in human keratinocytes: A new approach with future therapeutic potential

Journal of Photochemistry and Photobiology B: Biology 129: 93–99 (2013)

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Norbert Pardi, Hiromi Muramatsu, Drew Weissman, Katalin Karikó:

In vitro transcription of long RNA containing modified nucleosides

In: Rabinovich P. (eds): Synthetic Messenger RNA and Cell Metabolism Modulation. Methods in Molecular Biology (Methods and Protocols), vol. 969. Humana Press, Totowa, NJ, 2013, pp 29-42.

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Drew Weissman, Norbert Pardi, Hiro Muramatsu, Katalin Karikó:

HPLC purification of in vitro transcribed long RNA

In: Rabinovich P. (eds): Synthetic Messenger RNA and Cell Metabolism Modulation. Methods in Molecular Biology (Methods and Protocols), vol. 969. Humana Press, Totowa, NJ, 2013, pp 43-54.

2012

Katalin Karikó, Hiromi Muramatsu, Jason M Keller, Drew Weissman:

Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin [Original article]

Molecular Therapy 20(5): 948–953 (2012)

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Lauren H Sansing, Tajie H Harris, Scott E Kasner, Christopher A Hunter, Katalin Kariko:

Neutrophils and Toll-like receptor 4 contribute to injury after intracerebral hemorhage [Moderated poster Abstract, International Stroke Conference]

Stroke 43(Suppl.1): N^o 3822 (2012)

2011

Lauren H. Sansing, Tajie H. Harris, Frank A. Welsh, Scott E. Kasner, Christopher A. Hunter, Katalin Kariko:

Toll‐like receptor 4 contributes to poor outcome after intracerebral hemorrhage [Original article]

Annals of Neurology 70(4): 646–656 (2011)

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Lauren H. Sansing, Scott E. Kasner, Louise McCullough, Puneet Agarwal, FrankA. Welsh, Katalin Kariko:

Autologous blood injection to model spontaneous intracerebral hemorrhage in mice [Video article]

Journal of Visualized Experiments 54: e2618 (2011)

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Hiroki Kaneko, Sami Dridi, Valeria Tarallo, Bradley D. Gelfand, Benjamin J. Fowler, Won Gil Cho, Mark E. Kleinman, Steven L. Ponicsan, William W. Hauswirth, Vince A. Chiodo, Katalin Karikó, Jae Wook Yoo, Dong-ki Lee, Majda Hadziahmetovic, Ying Song, Smita Misra, Gautam Chaudhuri, Frank W. Buaas, Robert E. Braun, David R. Hinton, Qing Zhang, Hans E. Grossniklaus, Jan M. Provis, Michele C. Madigan, Ann H. Milam, Nikki L. Justice, Romulo J. C. Albuquerque, Alexander D. Blandford, Sasha Bogdanovich, Yoshio Hirano, Jassir Witta, Elaine Fuchs, Dan R. Littman, Balamurali K. Ambati, Charles M. Rudin, Mark M. W. Chong, Patrick Provost, Jennifer F. Kugel,James A. Goodrich, Joshua L. Dunaief, Judit Z. Baff, Jayakrishna Ambati:

DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration [Article]

Nature 471: 325–330 (2011)

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Bart R. Anderson, Hiromi Muramatsu, Babal K. Jha, Robert H. Silverman, Drew Weissman, Katalin Karikó:

Nucleoside modifications in RNA limit activation of 2′-5′-oligoadenylate synthetase and increase resistance to cleavage by RNase L

Nucleic Acids Research 39(21): 9329–9338 (2011)

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Katalin Karikó, Hiromi Muramatsu,János Ludwig, Drew Weissman:

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

Nucleic Acids Research 39(21): N^o e142 (2011)

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Lauren H. Sansing, Tajie H. Harris, Scott E. Kasner, Christopher A. Hunter, Katalin Kariko:

Neutrophil depletion diminishes monocyte infiltration and improves functional outcome after experimental intracerebral hemorrhage

In: Zhang J., Colohan A. (eds): Intracerebral Hemorrhage Research. Acta Neurochirurgica Supplementum, vol. 111. Springer, Vienna, 2011, pp 173-178.

2010

Bart R. Anderson, Hiromi Muramatsu, Subba R. Nallagatla, Philip C. Bevilacqua, Lauren H. Sansing, Drew Weissman, Katalin Karikó:

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

Nucleic Acids Research 38(17): 5884–5892 (2010)

2008

Katalin Karikó, Hiromi Muramatsu, Frank A Welsh, János Ludwig, Hiroki Kato, Shizuo Akira, Drew Weissman:

Incorporation of pseudouridine into mRNA yields superior nonimmunogenic vector with increased translational capacity and biological stability [Original article]

Molecular Therapy 16(11): 1833–1840 (2008)

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Mark E. Kleinman, Kiyoshi Yamada, Atsunobu Takeda, Vasu Chandrasekaran, Miho Nozaki, Judit Z. Baffi, Romulo J. C. Albuquerque, Satoshi Yamasaki, Masahiro Itaya, Yuzhen Pan, Binoy Appukuttan, Daniel Gibbs, Zhenglin Yang, Katalin Karikó, Balamurali K. Ambati, Traci A. Wilgus, Luisa A. DiPietro, Eiji Sakurai, Kang Zhang, Justine R. Smith, Ethan W. Taylor, Jayakrishna Ambati:

Sequence- and target-independentangiogenesis suppression by siRNA via TLR3 [Article]

Nature 452: 591-597 (2008)

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Katalin Karikó, Drew Weissman:

Impacts of nucleoside modification on RNA-mediated activation of Toll-like receptors [Chapter 13]

In: Ken J. Ishii, Shizuo Akira (eds): Nucleic Acids in Innate Immunity. CRC Press – Taylor & Francis Group, Boca Raton – London – New York, 2008, pp 171-188.

2007

Katalin Karikó, Drew Weissman:

Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: Implication for therapeutic RNA development

Current Opinion in Drug Discovery & Development 10(5): 523-532 (2007)

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Earl Stoddard, Georgetta Cannon, Houping Ni, Katalin Karikó, John Capodici, Daniel Malamud, Drew Weissman:

gp340 Expressed on human genital epithelia binds HIV-1 envelope protein and facilitates viral transmission

Journal of Immunology 179(5): 3126-3132 (2007)

2006

Hiromi Muramatsu, Frank A. Welsh, Katalin Karikó:

Cerebral preconditioning using cortical application of hypertonic salt solutions: Upregulation of mRNAs encoding inhibitors of inflammation [Research Report]

Brain Research 1097(1): 31-38 (2006)

2005

Katalin Karikó, Michael Buckstein, Houping Ni, Drew Weissman:

Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA

Immunity 23(2): 165-175 (2005)

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Katalin Karikó, Hiromi Muramatsu, Frank A. Welsh:

Cortical spreading depression elevates mRNAs encoding feedback inhibitors of inflammation: A novel mechanism of induced tolerance to ischemia [Research article]

Journal of Cerebral Blood Flow & Metabolism 25(1 Suppl): S283-S283 (2005)

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Hiromi Muramatsu, Katalin Karikó, Frank A. Welsh:

A small cortical lesion increases the expression of feedback inhibitors of proinflammatory cytokine-signaling [Research article]

Journal of Cerebral Blood Flow & Metabolism 25(1 Suppl): S295-S295 (2005)

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Shuwen Xu, Katalin Kariko, Gary Koski, Brian Czerniecki:

Toll-like receptor 8 agonist R-848 and IFN-γ synergize for IL-12 production by myeloid DC through expressions of Interferon Consensus Sequence Binding Protein (IRF-8) and Interferon Regulatory Factor-1 (IRF-1) [Abstract]

Proceedings of the American Association for Cancer Research 46: N^o 6001 (2005)

2004

Katalin Karikó, Prakash Bhuyan, John Capodici, Houping Ni, John Lubinski, Harvey Friedman, Drew Weissman:

Exogenous siRNA mediates sequence-independent gene suppression by signaling through Toll-like receptor 3

Cells Tissues Organs 177(3): 132–138 (2004)

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Katalin Karikó, Houping Ni, John Capodici, Marc Lamphier, Drew Weissman:

mRNA Is an endogenous ligand for Toll-like receptor 3

Journal of Biological Chemistry 279(13): 12542-12550 (2004)

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Hiromi Muramatsu, Katalin Karikó, Frank A. Welsh:

Induction of tolerance to focal ischemia in rat brain: dissociation between cortical lesioning and spreading depression

Journal of Cerebral Blood Flow & Metabolism 24(10): 1167–1171 (2004)

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Katalin Karikó, Drew Weissman, Frank A. Welsh:

Inhibition of Toll-like receptor and cytokine signaling – A unifying theme in ischemic tolerance

Journal of Cerebral Blood Flow & Metabolism 24(11): 1288–1304 (2004)

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Gary K. Koski, Katalin Karikó, Shuwen Xu, Drew Weissman, Peter A. Cohen and Brian J. Czerniecki:

Cutting edge: innate immune system discriminates between RNA containing bacterial versus eukaryotic structural features that prime for high-level IL-12 secretion by dendritic cells

Journal of Immunology 172(7): 3989-3993 (2004)

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Katalin Karikó, Prakash Bhuyan, John Capodici and Drew Weissman:

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through Toll-like receptor 3

Journal of Immunology 172(11): 6545-6549 (2004)

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Gary Koski, Katalin Kariko, Shuwen Xu, Drew Weissman, Brian Czerniecki:

Bacterial single-stranded RNA and its structural mimics activate high-level interleukin-12 secretion by human dendritic cells [Abstract]

19th Annual Scientific Meeting of the International Society for Biological Therapy of Cancer, San Francisco, 2004.

Journal of Immunotherapy 27(6): S25 (2004)

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Prakash K. Bhuyan, Katalin Karikó, John Capodici, John Lubinski, Lauren M. Hook, Harvey M. Friedman, Drew Weissman:

Short interfering RNA-mediated inhibition of herpes simplex virus type 1 gene expression and function during infection of human keratinocytes

Journal of Virology 78(19): 10276–10281 (2004)

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Shuwen Xu, Gary Koski, Katalin Kariko, Brian Czerniecki:

Toll like receptor 7/8 agonist R-848 primes DC for high IL-12 production and generates enhanced anti-tumor reactive CD8+ T cells [Abstract]

Proceedings of the American Association for Cancer Research 45: N^o4715 (2004)

2002

Bruce S. Sachais, Alice Kuo, Taher Nassar, Jeanelle Morgan, Katalin Kariko, Kevin Jon Williams, Michael Feldman ,Michael Aviram, Neelima Shah, Leonard Jarett, Mortimer Poncz, Douglas B. Cines, Abd Al-Roof Higaz:

Platelet factor 4 binds to low-density lipoprotein receptors and disrupts theendocytic itinerary, resulting in retention of low-density lipoproteinon the cell surface

Blood 99(10): 3613–3622 (2002)

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Houping Ni, John Capodici, Georgetta Cannon, Didier Communi, Jean-Marie Boeynaems, Katalin Karikó, Drew Weissman:

Extracellular mRNA induces dendritic cell activation by stimulating tumor necrosis factor-α secretion and signaling through a nucleotide receptor

Journal of Biological Chemistry 277(15): 12689-12696 (2002)

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John Capodici, Katalin Karikó, Drew Weissman:

Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference

Journal of Immunology 169(9): 5196-5201 (2002)

2001

Katalin Karikó, Jason M. Keller, Valerie A. Harris, David J. Langer, Frank A. Welsh:

In vivo protein expression from mRNA delivered into adult rat brain

Journal of Neuroscience Methods 105(1): 77-86 (2001)

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Yolanda M. Rangel, Katalin Kariko, Valerie A. Harris, Monica E. Duvall, Frank A. Welsh:

Dose-dependent induction of mRNAs encoding brain-derived neurotrophic factor and heat-shock protein-72 after cortical spreading depression in the rat [Research report]

Molecular Brain Research 88(1-2): 103-112 (2001)

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Kendall Mitchell, Katalin Kariko, Valerie A. Harris, Yolanda Rangel, Jason M. Keller, Frank A. Welsh:

Preconditioning with cortical spreading depression does not upregulate Cu/Zn-SOD or Mn-SOD in the cerebral cortex of rats [Research report]

Molecular Brain Research 96(1-2): 50-58 (2001)

2000

Hiroko Morisakia, Takayuki Morisakia, Katalin Kariko, Thomas Genetta, Edward W. Holmes:

Positive and negative elements mediate control of alternative splicing in the AMPD1 gene

Gene 246(1-2): 365-372 (2000)

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Drew Weissman, Houping Ni, David Scales, Annie Dude, John Capodici, Karen McGibney, Asha Abdool, Stuart N. Isaacs, Georgetta Cannon, Katalin Karikó:

HIV gag mRNA transfection of dendritic cells (DC) delivers encoded antigen to MHC class I and II molecules, causes DC maturation, and induces a potent human in vitro primary immune response

Journal of Immunology 165(8): 4710-4717 (2000)

1998

David G. Neschis, Shawn D. Safford, Puthiyaveettil N. Raghunath, David J. Langer, Mary L. David, Abigail K. Hanna, John E. Tomaszewski, Katalin Kariko, Elliot S. Barnathan, Michael A. Golden:

Thermal preconditioning before rat arterial balloon injury. Limitation of injury and sustained reduction of intimal thickening [Original Contributions]

Arteriosclerosis, Thrombosis, and Vascular Biology 18(1): 120-126 (1998)

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Katalin Karikó, Alice Kuob, Elliot S. Barnathan, David J. Langer:

Phosphate-enhanced transfection of cationic lipid-complexed mRNA and plasmid DNA

Biochimica et Biophysica Acta (BBA) - Biomembranes 1369(2): 320–334 (1998)

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Katalin Karikó, Valerie A. Harris, Yolanda Rangel, Monica E. Duvall, Frank A. Welsh:

Effect of cortical spreading depression on the levels of mRNA coding for putative neuroprotective proteins in rat brain

Journal of Cerebral Blood Flow and Metabolism 18(12): 1308-1315 (1998)

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Katalin Karikó, Elliot S. Barnathan:

A PCR-based approach to hammerhead ribozyme synthesis

In: Scanlon K. J. (eds): Therapeutic Applications of Ribozymes. Methods in Molecular Medicine, vol. 11. Springer, Totowa, NJ, 1998, pp 427-438.

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Steve Okada, Michael A. Golden, P. N. Raghunath, John E. Tomaszewski, Mary L. David, Alice Kuo, Katalin Kariko, Elliot S. Barnathan:

Native atherosclerosis and vein graft arterialization: association with increased urokinase receptor expression in vitro and in vivo [Rapid Communication]

Thrombosis and Haemostasis 80(01): 140-147 (1998)

1996

Hinke A. B. Multhaupt, Mats E. Gåfvels, Katalin Kariko, Hao Jin, Carmen Arenas-Elliott, Bruce I. Goldman, Jerome F. Strauss, BoAngelin, Micheal J.Warhol, Keith R. McCrae:

Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry

American Journal of Pathology 148(6): 1985–1997 (1996)

1995

Katalin Karikó, Helga Rosenbaum, Alice Kuo, Robert B. Zurier, Elliot S. Barnathan:

Stimulatory effect of unsaturated fatty acids on the level of plasminogen activator inhibitor‐1 mRNA in cultured human endothelial cells [Research Letter]

FEBS Letters 361(1): 118-122 (1995)

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Jean Bennett, Dexue Sun, Katalin Karikó:

Sequence analysis of the 5.34-kb 5′ flanking region of the human rhodopsin-encoding gene [Short communication]

Gene 167(1-2): 317-320 (1995)

1994

Katalin Karikó, Katalin Megyeri, Qi Xiao, Elliot S. Barnathan:

Lipofectin-aided cell delivery of ribozyme targeted to human urokinase receptor mRNA [Full-lenght Article]

FEBS Letters 352(1): 41-44 (1994)

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Hui Li, Alice Kuo, Jarema Kochan, Dudley Strickland, Katalin Kariko, Elliot S. Barnathan Douglas B. Cines:

Endocytosis of urokinase-plasminogen activator inhibitor type 1 complexes bound to a chimeric transmembrane urokinase receptor [Journal article]

Journal of Biological Chemistry 269(11): 8153-8158 (1994)

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Fengsheng Li, Elliot S. Barnathanand, Katalin Karikó:

Rapid method for screening and cloning cDNAs generated in differential mRNA display: application of northern blot for affinity capturing of cDNAs

Nucleic Acids Research 22(9): 1764–1765 (1994)

1993

Katalin Karikó, Alice Kuo, Douglas Boyd, S. Steve Okada, Douglas B. Cines, Elliott S. Barnathan:

Overexpression of urokinase receptor increases matrix invasion without altering cell migration in a human osteosarcoma cell line

Cancer Research 53(13): 3109-3117 (1993)

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David J. Langer, Alice Kuo, Katalin Kariko, Mena Ahuja, Bruce D. Klugherz, Katalin M. Ivanics, James A. Hoxie, William V. Williams, Bruce T. Liang, Douglas B. Cines, Elliot S. Barnathan:

Regulation of the endothelial cell urokinase-type plasminogen activator receptor. Evidence for cyclic AMP-dependent and protein kinase C-dependent pathways

Circulation Research 72(2): 330–340 (1993)

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Alexandra C. Miller, Katalin Kariko, Charles E. Myers, Edward P. Clark, Dvorit Samid:

Increased radioresistance of ejras‐transformed human osteosarcoma cells and its modulation by lovastatin, an inhibitor of p21^ras isoprenylation

International Journal of Cancer 53(2): 302-307 (1993)

1992

Jean-Marc Zini, Susan C. Murray, Charles H. Graham, Peeyush K. Lala, Katalin Karikó, Elliott S. Barnathan, Andrew Mazar, Jack Henkin, Douglas B. Cines, Keith R. McCrae:

Characterization of urokinase receptor expression by human placental trophoblasts

Blood 79(11): 2917–2929 (1992)

1990

Elliot S. Barnathan, Alice Kuo, Katalin Karikó, Louis Rosenfeld, Susan C. Murray, Niels Behrendt, Ebbe Rhne, David Weiner, Jack Henkin, Douglas B. Cines:

Characterization of human endothelial cell urokinase-type plasminogen activator receptor protein and messenger RNA

Blood 76(9): 1795–1806 (1990)

1989

Robert J. Suhadolnik, Bernard Lebleu, Wolfgang Pfleiderer, Ramamurthy Charubala, David C. Montefiori, William M. Mitchell, Robert W. Sobol, Jr., Shi Wu Li, Katalin Kariko, Nancy L. Reichenbach:

Phosphorothioate analogs of 2-5A: activation / inhibition of RNase L and inhibition of HIV-1 reverse transcriftase [Communication]

Nucleosides and Nucleotides 8(5-6): 987-990 (1989)

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Shi Wu Li, Robert W. Sobol Jr., Nancy L. Reichenbach, Katalin Kariko, Boyd E. Haley, Robert J. Suhadolnik:

2 and 8-azido ATP: photoaffinity labeling of 2-5A synthetase, enzymatic synthesis of 2 and 8-azido anamgs of 2-5A for use as photoaffinity probes of RNase L [Poster]

Nucleosides and Nucleotides 8(5-6): 1043-1044 (1989)

1988

Gerald E. Fronko, Robert J. Suhadolnik, Eric C. Vonderheid, Katalin Karikó, Nancy L. Reichenbach, Kenneth D. Chavin, Earl E. Henderson:

Decreased Epstein-Barr virus-induced transformation, and elevated 2–5A synthetase and RNase L activity in peripheral blood mononuclear cells from patients treated with recombinant interferon alfa 2b

Biochemical and Biophysical Research Communications 153(1): 448-453 (1988)

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Robert J. Suhadolnik, Katalin Kariko, Robert W. Sobol, Jr., Shi Wu Li, Nancy L. Reichenbach, Boyd E. Haley:

2- and 8-Azido photoaffinity probes. 1. Enzymic synthesis, characterization and biological properties of 2- and 8-azido photoprobes of 2-5A and photolabeling of 2-5A binding proteins

Biochemistry 27(24): 8840–8846 (1988)

1987

Katalin Kariko, Robert W. Sobol, Jr., Lorraine Suhadolnik, Shi Wu Li, Nancy Lee Reichenbach, Robert J. Suhadolnik, Ramamurthy Charubala, Wolfgang Pfleiderer:

Phosphorothioate analogs of 2',5'-oligoadenylate. Enzymatically synthesized 2',5'-phosphorothioate dimer and trimer: unequivocal structural assignment and activation of 2',5'-oligoadenylate-dependent endoribonuclease

Biochemistry 26(22): 7127–7135 (1987)

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Katalin Kariko, Shi Wu Li, Robert W. Sobol, Jr., Robert J. Suhadolnik, Ramamurthy Charubala, Wolfgang Pfleiderer:

Phosphorothioate analogs of 2',5'-oligoadenylate. Activation of 2',5'-oligoadenylate-dependent endoribonuclease by 2',5'-phosphorothioate cores and 5'-monophosphates

Biochemistry 26(22): 7136–7142 (1987)

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Robert J. Suhadolnik, Choongeun Lee, Katalin Kariko, Shi Wu Li:

Phosphorothioate analogs of 2',5'-oligoadenylate. Enzymic synthesis, properties, and biological activities of 2',5'-phosphorothioates from adenosine 5'-O-(2-thiotriphosphate) and adenosine 5'-O-(3-thiotriphosphate)

Biochemistry 26(22): 7143–7149 (1987)

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William A. Carter, Isadore Brodsky, Michael G. Pellegrino, Horace F. Henriques, David M. Parenti, Richard S. Schulof, W. Edward Robinson, David J. Volsky, Helene Paxton, Katalin Karikó, Robert J. Suhadolnik, David R. Strayer, Mark Lewin, Leo Einck, Gary L. Simon, Rochelle G. Scheib, David C. Montefiori, William M. Mitchell, Deborah Paul, William A. Meyer, III, Nancy Reichenbach, David H. Gillespie:

Clinical, immunological, and virological effects of ampligen, a mismatched double-stranded RNA, in patients with AIDS or AIDS-related complex

Lancet 329(8545): 1286-1292 (1987)

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Katalin Karikó, Shu Wu Li, Robert W. Sobol, Jr., Lorraine Suhadolnik, Nancy L. Reichenbach, Robert J. Suhadolnik, Ramamurthy Charubala, Wolfgang Pfleiderer:

Phosphorothioate analogs of 2–5A: elucidation of the stereochemical course of the enzymes of the 2–5A synthetase/RNase L system [Plenary Lecture]

7th Round Table Symposium on Nucleosides, Nucleotides and their Biological Application, University of Konstanz, 30 September – 3 October 1986.

Nucleosides and Nucleotides 6(1-2): 173-184 (1987)

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Katalin Karikó, Nancy L. Reichenbach, Robert J. Suhadolnik, Ramamurthy Charubala, Wolfgang Pfleiderer:

Cordycepin analogs of 2–5A as activators of RNase L: study of the structural requirements for RNase L activation [Poster]

Nucleosides and Nucleotides 6(1-2): 497-500 (1987)

1985

Katalin Karikó, János Ludwig:

n-Decyl-NHpppA2′p5′A2′p5′A a phosphatase-resistant, active pppA2′p5′A2′p5′A analog

Biochemical and Biophysical Research Communications 128(2): 695-698 (1985)